Chikungunya Virus Net is the web resource for anyone interested in chikungunya. Chikungunya virus (CHIKV) is an insect-borne virus, of the genus Alphavirus, that is spread by Aedes mosquitoes. Chikungunya infection causes fever and severe joint pain. Other symptoms include muscle pain, headache, nausea, fatigue and rash. The disease shares some clinical signs with dengue, and can be misdiagnosed in areas where dengue is common. There have been recent breakouts of chikungunya in Africa, Asia and the Indian subcontinent. In recent decades mosquito vectors of chikungunya have spread to Europe and the Americas. In 2007, disease transmission was reported for the first time in Europe. There is no cure for the disease. Treatment is focused on relieving the symptoms.

The objectives of Chikungunya Virus Net are to be the public and professional information resource for chikungunya and to serve as a network in the exchange of information and news related to chikungunya.

• Chikungunya on the Rise: Symptoms, Treatment, and Prevention ... - Healthnews.com
  Fri, 26 May 2023 07:00 GMT
• With rising cases, experts discuss Chikungunya spread in the ... - Pan American Health Organization
  Thu, 04 May 2023 07:00 GMT
• Uruguay: Local transmission of chikungunya reported in Montevideo ... - Outbreak News Today
  Fri, 26 May 2023 18:25 GMT
• Increased Chikungunya Cases Adds Urgency to Vaccine Race - Bloomberg
  Wed, 10 May 2023 07:00 GMT
• Update 87: Chikungunya: Experiences from the current response to ... - World Health Organization
  Wed, 10 May 2023 07:00 GMT
• Webinar: Clinical Diagnosis and Management of Chikungunya - Pan American Health Organization
  Tue, 16 May 2023 22:42 GMT
• Paraguay: Chikungunya cases decrease, but dengue fever is on the ... - Outbreak News Today
  Sun, 21 May 2023 11:33 GMT
• WHO Warns Americas Could See High Rates of Dengue And ... - Periódico Digital Centroamericano y del Caribe
  Tue, 09 May 2023 07:00 GMT
• A chikungunya virus–like particle vaccine induces broadly ... - Science
  Wed, 17 May 2023 07:00 GMT
• Effects of rIL2/anti-IL2 antibody complex on chikungunya virus ... - Nature.com
  Fri, 05 May 2023 07:00 GMT
• Paraguay: Chikungunya continues to expand outside the ... - Outbreak News Today
  Fri, 28 Apr 2023 07:00 GMT
• 'Brazil united against dengue, Zika and chikungunya'; Cases up in ... - Outbreak News Today
  Fri, 05 May 2023 07:00 GMT
• Health officials rush to Bailapur Tanda as dengue, chikungunya cases are reported - The Hindu
  Sun, 21 May 2023 14:02 GMT
• Peru: Minsa distributed nearly 11,000 tests for the timely detection of ... - Outbreak News Today
  Thu, 11 May 2023 07:00 GMT
• Density of Aedes aegypti (Diptera: Culicidae) in a low-income ... - Parasites & Vectors
  Sat, 06 May 2023 07:00 GMT

• PRO/AH/EDR> Rift Valley fever - Sudan: (NO) livestock, human, susp, RFI
  Wed, 15 Sep 2021 20:49:58 -0400
  Rift Valley Fever -- Sudan
  Doctors in Sudan's Northern State have reported 27 deaths and 68 [abortions] among livestock in the area of El Nafaab in Merowe locality and warn of the emergence of cases of Rift Valley fever [RVF] and chikungunya, similar to last year [2020]. They have appealed to the Ministry of Health and the state government to deal with the potential epidemic in a safe manner.
  In a press statement on Sunday [5 Sep 2021], the Socialist Doctors Association reported that a resident of the state arrived

• The Dimeric Peptide (KKYRYHLKPF)₂K Shows Broad-Spectrum Antiviral Activity by Inhibiting Different Steps of Chikungunya and Zika Virus Infection Sat, 27 May 2023 06:00:00 -0400
  Chikungunya virus (CHIKV) and Zika virus (ZIKV) are important disease-causing agents worldwide. Currently, there are no antiviral drugs or vaccines approved to treat these viruses. However, peptides have shown great potential for new drug development. A recent study described (p-BthTX-I)(2)K [(KKYRYHLKPF)(2)K], a peptide derived from the Bothropstoxin-I toxin in the venom of the Bothrops jararacussu snake, showed antiviral activity against SARS-CoV-2. In this study, we assessed the activity of...
• Effect of Viral Strain and Host Age on Clinical Disease and Viral Replication in Immunocompetent Mouse Models of Chikungunya Encephalomyelitis Sat, 27 May 2023 06:00:00 -0400
  The alphavirus chikungunya virus (CHIKV) represents a reemerging public health threat as mosquito vectors spread and viruses acquire advantageous mutations. Although primarily arthritogenic in nature, CHIKV can produce neurological disease with long-lasting sequelae that are difficult to study in humans. We therefore evaluated immunocompetent mouse strains/stocks for their susceptibility to intracranial infection with three different CHIKV strains, the East/Central/South African (ECSA) lineage...
• Chikungunya Virus Infection and Gonotrophic Cycle Shape Aedes aegypti Oviposition Behavior and Preferences Sat, 27 May 2023 06:00:00 -0400
  Targeting gravid females through chemical lures is a promising strategy in vector control; however, it requires the understanding of the factors susceptible to alter female oviposition behavior. Here, we evaluated the effect of infection with chikungunya virus (CHIKV) and the number of gonotrophic cycles (GCs) on oviposition activity in A. aegypti. Dual choice oviposition assays were performed, where dodecanoic acid, pentadecanoic acid, n-heneicosane and a Sargasssum fluitans (Børgesen) Børgesen...
• Characterization of an Aedes ADP-Ribosylation Protein Domain and Role of Post-Translational Modification during Chikungunya Virus Infection Sat, 27 May 2023 06:00:00 -0400
  Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which also leads to formation of polymer chains of ADP-ribose. ADP-ribosylation is reversible; its removal is carried out by ribosyl hydrolases such as PARG (poly ADP-ribose glycohydrolase), TARG (terminal ADP-ribose protein glycohydrolase), macrodomain,...
• Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever, and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology Sat, 27 May 2023 06:00:00 -0400
  Arboviruses, such as yellow fever virus (YFV), dengue virus (DENV), and chikungunya virus (CHIKV), present wide global dissemination and a pathogenic profile developed in infected individuals, from non-specific clinical conditions to severe forms, characterised by the promotion of significant lesions in different organs of the harbourer, culminating in multiple organ dysfunction. An analytical cross-sectional study was carried out via the histopathological analysis of 70 samples of liver...
• Mechanism of Immune Evasion in Mosquito-Borne Diseases Sat, 27 May 2023 06:00:00 -0400
  In recent decades, mosquito-borne illnesses have emerged as a major health burden in many tropical regions. These diseases, such as malaria, dengue fever, chikungunya, yellow fever, Zika virus infection, Rift Valley fever, Japanese encephalitis, and West Nile virus infection, are transmitted through the bite of infected mosquitoes. These pathogens have been shown to interfere with the host's immune system through adaptive and innate immune mechanisms, as well as the human circulatory system....
• Toxic Determination of Cry11 Mutated Proteins Obtained Using Rational Design and Its Computational Analysis Sat, 27 May 2023 06:00:00 -0400
  Cry11 proteins are toxic to Aedes aegypti, the vector of dengue, chikungunya, and Zika viruses. Cry11Aa and Cry11Bb are protoxins, which when activated present their active-toxin form in two fragments between 30 and 35 kDa respectively. Previous studies conducted with Cry11Aa and Cry11Bb genes using DNA shuffling generated variant 8, which presented a deletion in the first 73 amino acids and one at position 572 and 9 substitutions including L553F and L556W. In this study, variant 8 mutants were...
• The Diagnostic Potential of RNA Aptamers against the NS1 Protein of Dengue Virus Serotype 2 Sat, 27 May 2023 06:00:00 -0400
  Dengue infection, caused by the dengue virus, is a global threat which requires immediate attention and appropriate disease management. The current diagnosis of dengue infection is largely based on viral isolation, RT-PCR and serology-based detection, which are time-consuming and expensive, and require trained personnel. For early diagnosis of dengue, the direct detection of a dengue antigenic target is efficacious, and one such target is NS1. NS1-based detection is primarily antibody-centric...
• Integrated Plan of Insecticide Resistance Surveillance in Mosquito Vectors in France Fri, 26 May 2023 06:00:00 -0400
  Mosquito-borne diseases such as malaria, dengue, or chikungunya have been re-emerging all over the world, including in Europe. Managing resistance to public health pesticides in mosquitoes is essential and requires global, integrated, and coordinated actions and strong engagement of decision-makers, scientists, and public health operators. In this context, the present work aims at proposing an integrated plan of resistance surveillance in France and in the French Overseas territories in order to...
• Machine Learning Modeling of Aedes albopictus Habitat Suitability in the 21st Century Fri, 26 May 2023 06:00:00 -0400
  The Asian tiger mosquito, Aedes albopictus, is an important vector of arboviruses that cause diseases such as dengue, chikungunya, and zika. The vector is highly invasive and adapted to survive in temperate northern territories outside its native tropical and sub-tropical range. Climate and socio-economic change are expected to facilitate its range expansion and exacerbate the global vector-borne disease burden. To project shifts in the global habitat suitability of the vector, we developed an...