Chikungunya Virus Net is the web resource for anyone interested in chikungunya. Chikungunya virus (CHIKV) is an insect-borne virus, of the genus Alphavirus, that is spread by Aedes mosquitoes. Chikungunya infection causes fever and severe joint pain. Other symptoms include muscle pain, headache, nausea, fatigue and rash. The disease shares some clinical signs with dengue, and can be misdiagnosed in areas where dengue is common. There have been recent breakouts of chikungunya in Africa, Asia and the Indian subcontinent. In recent decades mosquito vectors of chikungunya have spread to Europe and the Americas. In 2007, disease transmission was reported for the first time in Europe. There is no cure for the disease. Treatment is focused on relieving the symptoms.

The objectives of Chikungunya Virus Net are to be the public and professional information resource for chikungunya and to serve as a network in the exchange of information and news related to chikungunya.

• SLU Researchers Begin Enrolling Participants in Chikungunya Vaccine Clinical Trial : SLU - Saint Louis University
  Wed, 19 Jan 2022 17:44 GMT
• Consensus-Conference Endorsements and Recommendations on the Diagnosis and Treatment of Chikungunya-Related... - Physician's Weekly
  Tue, 04 Jan 2022 08:00 GMT
• Cartagena warns of potential Dengue and Chikungunya outbreaks - The City Paper Bogotá
  Fri, 21 Jan 2022 15:49 GMT
• Mumbai: No dengue, H1N1 and chikungunya in January so far - Times of India
  Wed, 12 Jan 2022 08:00 GMT
• Chikungunya Treatment Market 2022 Business Outlook with Pandemic Scenario Analysis and Forecast 2028 – The Oxford Spokesman - The Oxford Spokesman
  Tue, 25 Jan 2022 18:13 GMT
• World NTD Day 2022: What Are Neglected Tropical Diseases? | TheHealthSite.com - TheHealthSite
  Fri, 28 Jan 2022 13:31 GMT
• What chikungunya teaches us about COVID-19 - The Lancet
  Wed, 19 May 2021 07:00 GMT
• Brazil: 8 Mayaro virus cases reported in Pará in 2021 - Outbreak News Today - Outbreak News Today
  Thu, 27 Jan 2022 14:08 GMT
• Chikungunya: What are the symptoms; all you need to know - India Today
  Thu, 26 Aug 2021 07:00 GMT
• Epidemiological Update: Dengue, Chikungunya and Zika in the context of COVID-19 (23 December 2021) - Argentina - ReliefWeb
  Fri, 24 Dec 2021 08:00 GMT
• Valneva's Chikungunya vaccine gets FDA breakthrough designation - BioPharma-Reporter.com
  Thu, 08 Jul 2021 07:00 GMT
• Exposure to Chikungunya may offer partial cross-protection against Mayaro virus - News-Medical.Net
  Sat, 04 Dec 2021 08:00 GMT
• So Far, So Good for Chikungunya Vaccine in Phase III Trial - MedPage Today
  Sun, 21 Nov 2021 08:00 GMT
• First-Ever Single-Dose Chikungunya Vaccine Touts Positive Phase III Results - BioSpace
  Thu, 05 Aug 2021 07:00 GMT
• Chikungunya Vaccine First to Succeed in Phase III Trial - Labiotech.eu
  Thu, 19 Aug 2021 07:00 GMT

• PRO/AH/EDR> Rift Valley fever - Sudan: (NO) livestock, human, susp, RFI
  Wed, 15 Sep 2021 20:49:58 -0400
  Rift Valley Fever -- Sudan
  Doctors in Sudan's Northern State have reported 27 deaths and 68 [abortions] among livestock in the area of El Nafaab in Merowe locality and warn of the emergence of cases of Rift Valley fever [RVF] and chikungunya, similar to last year [2020]. They have appealed to the Ministry of Health and the state government to deal with the potential epidemic in a safe manner.
  In a press statement on Sunday [5 Sep 2021], the Socialist Doctors Association reported that a resident of the state arrived

• Discovery and development of labdane-oxindole hybrids as small-molecule inhibitors against chikungunya virus infection Thu, 27 Jan 2022 06:00:00 -0500
  Chikungunya virus (CHIKV) infection, a febrile illness caused by a mosquito-transmitted alphavirus, has afflicted millions of people worldwide. There is currently no approved effective antiviral treatment for CHIKV infection. In this study, we report a new class of small-molecule CHIKV inhibitors, the oxindole-labdanes, that potently block the replication of CHIKV with good selectivity. Andrographolide, a previously reported inhibitor of CHIKV infection, was used as the lead compound for our...
• Comparison of Illumina and Oxford Nanopore sequencing technologies for pathogen detection from clinical matrices using molecular inversion probes Thu, 27 Jan 2022 06:00:00 -0500
  Next-generation sequencing is rapidly finding footholds in numerous microbiological fields including infectious disease diagnostics. Here, we describe a molecular inversion probe panel for the identification of bacterial, viral and parasitic pathogens. We demonstrate the ability of Illumina and Oxford Nanopore Technologies to sequence small amplicons originating from this panel for the identification of pathogens in complex matrices. The panel correctly classified 31 bacterial pathogens directly...
• Emerging tropical neurological infections Wed, 26 Jan 2022 06:00:00 -0500
  A large majority of neurological infections remain undiagnosed worldwide. Emerging and re-emerging infections are likely to be responsible for a significant proportion of these. Over the last two decades, several new organisms producing neurological infection and the neurotropic potential of many other known pathogens have been identified. Large outbreaks caused by re-emerging pathogens such as Chikungunya virus, Zika virus and Ebola virus have led to better delineation of their neurological...
• Downregulation of CD73 on CD4+ T cells from patients with chronic Chikungunya infection Wed, 26 Jan 2022 06:00:00 -0500
  Chikungunya is an important mosquito-borne disease caused by the arthritogenic chikungunya virus, characterized by sporadic outbreaks all around the world. Although CD4+ T cells seem to have an important role in the pathogenesis of chikungunya, the mechanisms involved in this process are not yet fully elucidated. The ectoenzymes CD39 and CD73, also expressed by CD4 T lymphocytes, are involved in the hydrolysis of pro-inflammatory extracellular ATP and generation of immunosuppressive adenosine...
• Antenatal Seroprevalence of Zika and Chikungunya Viruses, Kingston Metropolitan Area, Jamaica, 2017-2019 Tue, 25 Jan 2022 06:00:00 -0500
  To determine the extent of exposure to Zika virus (ZIKV) and chikungunya virus (CHIKV) in Jamaica, we collected serum from 584 pregnant women during 2017-2019. We found that 15.6% had antibodies against ZIKV and 83.6% against CHIKV. These results indicate potential recirculation of ZIKV but not CHIKV in the near future.
• G-quadruplex ligands inhibit chikungunya virus replication Tue, 25 Jan 2022 06:00:00 -0500
  Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus affecting human health globally. G-quadruplex secondary structures attract great attention as potential targets for antiviral strategy. In this study, we show that CHIKV genome possesses several conserved potential G-quadruplex sequences. G-quadruplex ligands BRACO-19 and TMPyP4 could stabilize the CHIKV G-quadruplex and inhibit the transcription of constructs containing CHIKV G-quadruplex sequences. Importantly, BRACO-19 and TMPyP4...
• A case of co-infection with malaria and chikungunya in a returning traveler from Nigeria Tue, 25 Jan 2022 06:00:00 -0500
  Due to globalization, physicians have to be prepared with knowledge and understanding of cases and diseases from all over the world. Vector-borne diseases are a particular group of diseases for which the clinician should be prepared, especially in the context of returning travelers with tropical fever, as the symptoms are very similar among some of the pathogens. In this report we present a case of a returning traveler from Nigeria with fever as her chief complaint and with a final diagnosis of...
• Molecular xenomonitoring of Dengue, Chikungunya and Zika infections: a year-round study from two Dengue endemic districts of central India Tue, 25 Jan 2022 06:00:00 -0500
  BACKGROUND & OBJECTIVES: Infections caused by arboviruses and transmitted by Aedes species mosquitoes are a serious health concern. India is endemic for diseases like Dengue, Chikungunya and recently Zika has been reported from few states. Vector control is the only way to contain these diseases, however, data regarding vectors from central India is lacking; to fulfill the lacuna we conducted this study.
• Correction to: Chikungunya outbreak in Bangladesh (2017): sociodemographic and clinical characteristics of patients from three hotspots Tue, 25 Jan 2022 06:00:00 -0500
  No abstract
• Spatiotemporal distribution, abundance, and host interactions of two invasive vectors of arboviruses, Aedes albopictus and Aedes japonicus, in Pennsylvania, USA Tue, 25 Jan 2022 06:00:00 -0500
  CONCLUSIONS: Extensive distribution, high abundance, and frequent interactions with mammalian hosts suggest potential involvement of Ae. albopictus and Ae. japonicus in the transmission of human arboviruses including Cache Valley, Jamestown Canyon, La Crosse, dengue, chikungunya, and Zika should any of these viruses become prevalent in Pennsylvania. Limited interaction with avian hosts suggests that Ae. albopictus might occasionally be involved in transmission of arboviruses such as West Nile in...