Chikungunya Virus Net is the web resource for anyone interested in chikungunya. Chikungunya virus (CHIKV) is an insect-borne virus, of the genus Alphavirus, that is spread by Aedes mosquitoes. Chikungunya infection causes fever and severe joint pain. Other symptoms include muscle pain, headache, nausea, fatigue and rash. The disease shares some clinical signs with dengue, and can be misdiagnosed in areas where dengue is common. There have been recent breakouts of chikungunya in Africa, Asia and the Indian subcontinent. In recent decades mosquito vectors of chikungunya have spread to Europe and the Americas. In 2007, disease transmission was reported for the first time in Europe. There is no cure for the disease. Treatment is focused on relieving the symptoms.

The objectives of Chikungunya Virus Net are to be the public and professional information resource for chikungunya and to serve as a network in the exchange of information and news related to chikungunya.

• Valneva Initiates Phase 3 Clinical Lot Consistency Study for its Single-Shot Chikungunya Vaccine Candidate - GlobeNewswire
  Mon, 22 Feb 2021 08:00 GMT
• Valneva initiates Phase 3 study for its chikungunya vaccine candidate - Homeland Preparedness News
  Wed, 24 Feb 2021 15:20 GMT
• Scientists use machine-learning approach to track disease-carrying mosquitoes - Science Daily
  Mon, 22 Feb 2021 19:52 GMT
• Checking on Chikungunya - NASA - NASA - NASA
  Mon, 27 Jul 2020 07:00 GMT
• Structural basis of Chikungunya virus inhibition by monoclonal antibodies - pnas.org
  Wed, 21 Oct 2020 07:00 GMT
• Overview of the COVID-19 pandemic - World Health Organization
  Tue, 02 Mar 2021 18:15 GMT
• Using landscape connectivity to control deadly mosquito-borne viruses - Science Daily
  Wed, 24 Feb 2021 03:22 GMT
• Chikungunya Virus Nucleic Acid Detection Kit Market Demand & Future Scope Including Top Players – NeighborWebSJ - NeighborWebSJ
  Sun, 28 Feb 2021 17:56 GMT
• Chikungunya may affect central nervous system as well as joints and lungs - EurekAlert
  Wed, 04 Nov 2020 08:00 GMT
• Chikungunya treatment Market Expected to Witness High Growth over the Forecast to 2026 – KSU | The Sentinel Newspaper - KSU | The Sentinel Newspaper
  Wed, 24 Feb 2021 16:47 GMT
• Anterior uveitis often associated with Zika virus infection - Healio
  Mon, 01 Mar 2021 21:04 GMT
• Chikungunya Fever Drugs Market Size 2021 | Industry Growth Analysis by Key Players – Abivax SA, Inovio Pharmaceuticals Inc, Ennaid Therapeutics LLC, Arno Therapeutics Inc, Indian Immunologicals Ltd - NY Market Reports
  Mon, 01 Mar 2021 05:21 GMT
• Valneva Reports FY 2020 Results and Major Corporate Achievements - GlobeNewswire
  Thu, 25 Feb 2021 06:00 GMT
• Chikungunya health topic - World Health Organization
  Wed, 09 Oct 2019 17:43 GMT
• When and where will millions of mosquitoes be released? Here are details for Florida Keys - Miami Herald
  Thu, 25 Feb 2021 11:00 GMT

• PRO/AH/EDR> Chikungunya (01): Americas, Africa
  Thu, 04 Feb 2021 06:49:49 -0500
  Chikungunya -- Brazil
  

• Facilitating Understanding, Modeling and Simulation of Infectious Disease Epidemics in the Age of COVID-19 Mon, 01 Mar 2021 06:00:00 -0500
  Interest in the mathematical modeling of infectious diseases has increased due to the COVID-19 pandemic. However, many medical students do not have the required background in coding or mathematics to engage optimally in this approach. System dynamics is a methodology for implementing mathematical models as easy-to-understand stock-flow diagrams. Remarkably, creating stock-flow diagrams is the same process as creating the equivalent differential equations. Yet, its visual nature makes the process...
• Co-circulation and misdiagnosis led to underestimation of the 2015-2017 Zika epidemic in the Americas Mon, 01 Mar 2021 06:00:00 -0500
  During the 2015-2017 Zika epidemic, dengue and chikungunya-two other viral diseases with the same vector as Zika-were also in circulation. Clinical presentation of these diseases can vary from person to person in terms of symptoms and severity, making it difficult to differentially diagnose them. Under these circumstances, it is possible that numerous cases of Zika could have been misdiagnosed as dengue or chikungunya, or vice versa. Given the importance of surveillance data for informing...
• Mayaro virus detection in patients from rural and urban areas in Trinidad and Tobago during the Chikungunya and Zika virus outbreaks Mon, 01 Mar 2021 06:00:00 -0500
  Mayaro virus, which can often go undetected due to its clinical manifestations and intimate alignment with dengue and chikungunya viruses, is one of the most neglected arboviruses. The virus has been found in several outbreaks, where a moderate-to-severe and potentially incapacitating joint disease has been observed. MAYV usually circulates in a sylvan cycle of forest mosquitoes and vertebrates, causing sporadic sylvatic infections to humans, and some outbreaks in sub-urban areas. This study...
• Value of C-reactive protein in differentiating viral from bacterial aetiologies in patients with non-malaria acute undifferentiated fever in tropical areas: a meta-analysis and individual patient data study Mon, 01 Mar 2021 06:00:00 -0500
  C-reactive protein (CRP) is used to discriminate common bacterial and viral infections, but its utility in tropical settings remains unknown. We performed a meta-analysis of studies performed in Asia and Africa. First, mean CRP levels for specific tropical infections were calculated. Thereafter, individual patient data (IPD) from patients with non-malarial undifferentiated fever (NMUF) who were tested for viral and bacterial pathogens were analysed, calculating separate cut-off values and their...
• A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins Mon, 01 Mar 2021 06:00:00 -0500
  Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a variety of host proteins associated with stress granules (SGs). The HVD displays the highest variability across the more than 30 known alphaviruses, yet it also contains several motifs that are conserved amongst different subgroups of alphaviruses....
• Arbovirus Rash in the Febrile Returning Traveler as a Diagnostic Clue Mon, 01 Mar 2021 06:00:00 -0500
  PURPOSE OF REVIEW: This review aims to describe briefly the general information of arboviruses dengue, Zika, and chikungunya infections and emphasize the clinical manifestations of each, to help identify and make a quick diagnosis of each.
• Computational analysis revealed miRNAs produced by Chikungunya virus target genes associated with antiviral immune responses and cell cycle regulation Sun, 28 Feb 2021 06:00:00 -0500
  Chikungunya virus (CHIKV) that causes chikungunya fever, is an alphavirus that belongs to the Togaviridae family containing a single-stranded RNA genome. Mosquitoes of the Aedes species act as the vectors for this virus and can be found in the blood, which can be passed from an infected person to a mosquito through mosquito bites. CHIKV has drawn much attention recently because of its potential of causing an epidemic. As the detailed mechanism of its pathogenesis inside the host system is still...
• In vitro and in vivo studies reveal alpha-Mangostin, a xanthonoid from Garcinia mangostana, as a promising natural antiviral compound against chikungunya virus Sun, 28 Feb 2021 06:00:00 -0500
  CONCLUSIONS: The findings suggest that α-Mangostin can inhibit CHIKV infection and replication through possible interaction with multiple CHIKV target proteins and might act as a prophylactic/therapeutic agent against CHIKV.
• Deep learning identification for citizen science surveillance of tiger mosquitoes Fri, 26 Feb 2021 06:00:00 -0500
  Global monitoring of disease vectors is undoubtedly becoming an urgent need as the human population rises and becomes increasingly mobile, international commercial exchanges increase, and climate change expands the habitats of many vector species. Traditional surveillance of mosquitoes, vectors of many diseases, relies on catches, which requires regular manual inspection and reporting, and dedicated personnel, making large-scale monitoring difficult and expensive. New approaches are solving the...
• Fully automated point-of-care differential diagnosis of acute febrile illness Thu, 25 Feb 2021 06:00:00 -0500
  CONCLUSIONS/SIGNIFICANCE: The FeverDisk proved to be universally applicable as it successfully detected all different types of pathogens as single or co-infections, while it also managed to define the serotype of un-serotyped dengue samples. Thirty-eight FeverDisks at the two African sites provided 59 assay results, out of which 51 (86.4%) were confirmed with reference assay results. The results provide a promising outlook for future implementation of the platform in larger prospective clinical...