Chikungunya Virus Net is the web resource for anyone interested in chikungunya. Chikungunya virus (CHIKV) is an insect-borne virus, of the genus Alphavirus, that is spread by Aedes mosquitoes. Chikungunya infection causes fever and severe joint pain. Other symptoms include muscle pain, headache, nausea, fatigue and rash. The disease shares some clinical signs with dengue, and can be misdiagnosed in areas where dengue is common. There have been recent breakouts of chikungunya in Africa, Asia and the Indian subcontinent. In recent decades mosquito vectors of chikungunya have spread to Europe and the Americas. In 2007, disease transmission was reported for the first time in Europe. There is no cure for the disease. Treatment is focused on relieving the symptoms.

The objectives of Chikungunya Virus Net are to be the public and professional information resource for chikungunya and to serve as a network in the exchange of information and news related to chikungunya.

• Investigational Vaccine Gets Breakthrough Tx Status for Chikungunya Disease - Monthly Prescribing Reference
  Wed, 07 Jul 2021 07:00 GMT
• Mapping dengue hot spots pinpoints risks for Zika and chikungunya - Emory News Center
  Wed, 07 Jul 2021 07:00 GMT
• Dengue, malaria cases decline in TN in last five years, but chikungunya on the rise - The New Indian Express
  Mon, 02 Aug 2021 13:04 GMT
• First chikungunya case reported in two years in Punjab - The Tribune
  Sun, 25 Jul 2021 01:51 GMT
• First case of Chikungunya after a gap of 2years; officials on toes - The Tribune
  Sat, 24 Jul 2021 07:00 GMT
• Risk Areas for Zika and Chikungunya Pinpointed by Mapping Dengue Hotspots - Technology Networks
  Thu, 08 Jul 2021 07:00 GMT
• Valneva's Chikungunya vaccine gets FDA breakthrough designation - BioPharma-Reporter.com
  Thu, 08 Jul 2021 07:00 GMT
• Maharashtra reports first Zika virus case in Pune, mixed with Chikungunya - ANI News
  Sun, 01 Aug 2021 21:55 GMT
• Mapping Dengue Hot Spots Can Pinpoint Zika, Chikungunya Risk - PCT Magazine
  Tue, 20 Jul 2021 19:13 GMT
• Valneva's chikungunya virus vaccine granted breakthrough designation - PharmaTimes
  Fri, 09 Jul 2021 07:00 GMT
• Parent’s Guide: 11 things you need to know about Chikungunya, a mosquito-borne disease - Yahoo Philippines News
  Mon, 05 Jul 2021 21:09 GMT
• Not just Covid, also be wary of chikungunya in Ludhiana - Hindustan Times
  Mon, 26 Jul 2021 20:19 GMT
• Chikungunya: Valneva awarded Breakthrough Therapy Designation for vaccine candidate - Outbreak News Today - Outbreak News Today
  Sun, 11 Jul 2021 07:00 GMT
• Brazil: Chikungunya cases up dramatically in São Paulo - Outbreak News Today - Outbreak News Today
  Mon, 05 Jul 2021 07:00 GMT
• Chikungunya Vaccine Digital Symposium Scheduled for July 9th - PrecisionVaccinations
  Tue, 06 Jul 2021 07:00 GMT

• PRO/AH/EDR> Invasive mosquito - France (02): (CN) spread
  Sun, 04 Jul 2021 13:46:20 -0400
  Not Yet Classified -- France
  After Indre, Cher and Indre-et-Loire, now the tiger mosquito [_Aedes albopictus_] has been reported in Loiret, and colonization of the territory is inevitable, the regional health agency estimates, but we can adopt measures to limit its rapid spread.
  This mosquito is establishing itself more and more on French soil in [metropolitan] France and is a vector of diseases [viruses] such as chikungunya, dengue fever and Zika. The Regional Health Agency [ARS] of the Centre-Val de Loire issued an

• Social Stressors, Arboviral Infection, and Immune Dysregulation in the Coastal Lowland Region of Ecuador: A Mixed Methods Approach in Ecological Perspective Mon, 02 Aug 2021 06:00:00 -0400
  Aedes aegypti, the mosquito that transmits arboviral diseases such as dengue (DENV), chikungunya (CHIKV), and Zika viruses (ZIKV), is present in tropical and subtropical regions of the world. Individuals at risk of mosquito-borne disease (MBD) in the urban tropics face daily challenges linked to their socio-environment conditions, such as poor infrastructure, poverty, crowding, and limited access to adequate healthcare. These daily demands induce chronic stress events and dysregulated immune...
• Chikungunya Fever in Southern Thailand, 2018 Mon, 02 Aug 2021 06:00:00 -0400
  Infection by the mosquito-borne chikungunya virus (CHIKV) causes acute febrile illness and debilitating arthralgia. Outbreaks are sometimes not recognized because of its clinical resemblance to the more common dengue fever ubiquitous in tropical countries. An upsurge of dengue-like illness was reported in Satun province located in southern Thailand during the rainy season in 2018. We investigated probable outbreak of CHIKV disease. We collected serum samples from 127 patients and tested for...
• Clinical Features of Acute Chikungunya Virus Infection in Children and Adults during an Outbreak in the Maldives Mon, 02 Aug 2021 06:00:00 -0400
  The chikungunya virus is an arthritogenic arbovirus that has re-emerged in many tropical and subtropical regions, causing explosive outbreaks. This re-emergence is due to a genomic polymorphism that has increased the vector susceptibility of the virus. The majority of those infected with chikungunya virus exhibit symptoms of fever, rash, and debilitating polyarthralgia or arthritis. Symptoms can persist for weeks, and patients can relapse months later. Fatalities are rare, but individuals of...
• Spatial analysis of the incidence of dengue, Zika, and chikungunya and socioeconomic determinants in the city of Rio de Janeiro, Brazil Mon, 02 Aug 2021 06:00:00 -0400
  No abstract
• Prevalence and trend of emerging and re-emerging arboviral infections in the state of Odisha Mon, 02 Aug 2021 06:00:00 -0400
  Newly emerging or re-emerging infections are posing continuous threat to both public health system and clinical care globally. The emergence of infections especially caused by arboviruses can be linked to several mechanisms which include geographical expansion linked to human development and transportation, global warming, enhanced transmission in peridomestic area and close proximity of human habitations to domestic as well as wild animals. The co-circulation of Dengue, Chikungunya and Zika is...
• Chronic Joint Pain 3 Years after Chikungunya Virus Infection Largely Characterized by Relapsing-remitting Symptoms Mon, 02 Aug 2021 06:00:00 -0400
  No abstract
• Correlative imaging using super-resolution fluorescence microscopy and soft X-ray tomography at cryogenic temperatures provides a new way to assess virosome solutions for vaccine development Sun, 01 Aug 2021 06:00:00 -0400
  Active Virosomes (AVs) are derivatives of viruses, broadly similar to 'parent' pathogens, with an outer envelope that contains a bespoke genome coding for 4-5 viral proteins capable of eliciting an antigenic response. AVs are essentially novel vaccine formulations that present on their surface selected viral proteins as antigens. Once administered, they elicit an initial "anti-viral" immune response. AVs are also internalised by host cells where their cargo viral genes are used to express viral...
• Computational identification of repurposed drugs against viruses causing epidemics and pandemics via drug-target network analysis Sat, 31 Jul 2021 06:00:00 -0400
  Viral epidemics and pandemics are considered public health emergencies. However, traditional and novel antiviral discovery approaches are unable to mitigate them in a timely manner. Notably, drug repurposing emerged as an alternative strategy to provide antiviral solutions in a timely and cost-effective manner. In the literature, many FDA-approved drugs have been repurposed to inhibit viruses, while a few among them have also entered clinical trials. Using experimental data, we identified...
• A single dose of ChAdOx1 Chik vaccine induces neutralizing antibodies against four chikungunya virus lineages in a phase 1 clinical trial Sat, 31 Jul 2021 06:00:00 -0400
  Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that causes swift outbreaks. Major concerns are the persistent and disabling polyarthralgia in infected individuals. Here we present the results from a first-in-human trial of the candidate simian adenovirus vectored vaccine ChAdOx1 Chik, expressing the CHIKV full-length structural polyprotein (Capsid, E3, E2, 6k and E1). 24 adult healthy volunteers aged 18-50 years, were recruited in a dose escalation, open-label, nonrandomized and...
• Targeting cap-dependent translation to inhibit Chikungunya virus replication: selectivity of p38 MAPK inhibitors to virus-infected cells due to autophagy-mediated down regulation of phospho-ERK Fri, 30 Jul 2021 06:00:00 -0400
  The 5' capped, message-sense RNA genome of Chikungunya virus (CHIKV) utilizes the host cell machinery for translation. Translation is regulated by eIF2 alpha at the initiation phase and by eIF4F at cap recognition. Translational suppression by eIF2 alpha phosphorylation occurs as an early event in many alphavirus infections. We observe that in CHIKV-infected HEK293 cells, this occurs as a late event, by which time the viral replication has reached an exponential phase, implying its minimal role...