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Latest Articles on Chikungunya

  • Antisynthetase Syndrome after chikungunya infection: A case report Thu, 29 Sep 2022 06:00:00 -0400
    Chikungunya is an arboviral disease caused by a virus with wide geographical distribution in endemic areas. This case report documents a patient with antisynthetase syndrome post-chikungunya infection. Autoimmune diseases result from breakdown of immune tolerance. Among all triggers, viruses represent the greatest environmental potential to precipitate inflammatory myopathy.
  • Comprehensive Molecular Interaction Studies to Construe the Repellent/Kill Activity of Geraniol During Binding Event Against Aedes aegypti Proteins Wed, 28 Sep 2022 06:00:00 -0400
    Aedes aegypti is an etiological agent for dengue, chikungunya, zika, and yellow fever viruses. With the advent of the use of natural alternatives as repellents, their precise mode of action during the event of binding is still unclear. Geraniol is one such bioactive natural that has been previously shown to have some insecticide properties. Thus, the present study aimed to understand the mechanism of the binding event of geraniol with the whole proteome of A. aegypti. Twenty protein target...
  • Arbovirus detection in synanthropic mosquitoes from the Brazilian Amazon and in mosquito saliva using Flinders Technology Associates cards Tue, 27 Sep 2022 06:00:00 -0400
    Although arbovirus transmission and identifying target vectors may provide a baseline for planning disease control strategies, there are many gaps in knowledge regarding these mosquitoes and viral species in urban, rural, or sylvatic habitats in the Brazilian Amazon. Our goal was to screen for dengue, chikungunya, and Zika viruses in synanthropic mosquitoes and with Flinders Technology Associates (FTA) cards using insect saliva. Mosquitoes were caught using ovitraps and aspirators in the city of...
  • The lncRNA ALPHA specifically targets chikungunya virus to control infection Tue, 27 Sep 2022 06:00:00 -0400
    Arthropod-borne viruses, including the alphavirus chikungunya virus (CHIKV), cause acute disease in millions of people and utilize potent mechanisms to antagonize and circumvent innate immune pathways including the type I interferon (IFN) pathway. In response, hosts have evolved antiviral counterdefense strategies that remain incompletely understood. Recent studies have found that long noncoding RNAs (lncRNAs) regulate classical innate immune pathways; how lncRNAs contribute to additional...
  • Tumor necrosis factor plays a deleterious role in the pathogenesis of chikungunya virus infection Tue, 27 Sep 2022 06:00:00 -0400
    Arthralgia is a hallmark of chikungunya virus (CHIKV) infection and can be very debilitating and associated with a robust local inflammatory response. Many pathophysiological aspects associated with the disease remain to be elucidated. Here, we describe a novel model of CHIKV infection in immunocompetent mice and evaluate the role of tumor necrosis factor in the pathogenesis of the disease. C57BL/6 wild type (WT) or TNF receptor 1 deficient (TNFR1^(-/-) ) mice were inoculated with 1x10⁶ PFU of...
  • Dataset of vector mosquito images Tue, 27 Sep 2022 06:00:00 -0400
    Mosquitoes pose substantial threat to public health resulting in million number of deaths wordlwide every year. They act as the vectors responsible for diseases such as Dengue, Yellow fever,Chikungunya, Zika etc. The harmful mosquito species are contained in the genera Aedes, Anopheles and Culex. Automated species identification of vectors is essential to implement targeted vector control strategies. The objective of the proposed paper is to construct a novel dataset of images of dangerous...
  • Influence of epidemics and pandemics on paediatric ED use: a systematic review Mon, 26 Sep 2022 06:00:00 -0400
    CONCLUSIONS: The scale and direction of effect of PED use depend on both the epidemic disease, the public health measures enforced and how these influence decision-making. Policy makers must be aware how fear of virus among the general public may influence their response to public health advice. There is large inequity in reporting of epidemic impact on PED use which needs to be addressed.
  • In Depth Viral Diversity Analysis in Atypical Neurological and Neonatal Chikungunya Infections in Rio de Janeiro, Brazil Fri, 23 Sep 2022 06:00:00 -0400
    Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) transmitted by Aedes mosquitoes. The human infection usually manifests as a febrile and incapacitating arthritogenic illness, self-limiting and non-lethal. However, since 2013, CHIKV spreading through the tropics and to the Americas was accompanied by an increasing number of cases of atypical disease presentation, namely severe neuropathies and neonatal infection due to intrapartum vertical transmission. The pathophysiological...
  • Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis Fri, 23 Sep 2022 06:00:00 -0400
    Dengue fever, chikungunya, and zika are highly prevalent arboviruses transmitted by hematophagous arthropods, with a widely neglected impact in developing countries. These diseases cause acute illness in diverse populations, as well as potential cardiovascular complications. A systematic review was carried out to investigate the burden of cardiac involvement related to these arboviruses. Multiple databases were searched for articles that investigated the association of cardiovascular diseases...
  • Viral Metagenomics for the Identification of Emerging Infections in Clinical Samples with Inconclusive Dengue, Zika, and Chikungunya Viral Amplification Fri, 23 Sep 2022 06:00:00 -0400
    Viral metagenomics is increasingly being used for the identification of emerging and re-emerging viral pathogens in clinical samples with unknown etiology. The objective of this study was to shield light on the metavirome composition in clinical samples obtained from patients with clinical history compatible with an arboviral infection, but that presented inconclusive results when tested using RT-qPCR. The inconclusive amplification results might be an indication of the presence of an emerging...

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